The original post got too long as a single post. This post is a split, part 2 with updates. I suggest that you read this and the last one because they both have new important info and citations. This post will discuss how COVID-19 attacks it’s host and how to mitigate the damage.

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Disclaimer

Our discussion here will be on how COVID-19 attacks it’s host. The author does not intend to diagnose, treat, or cure COVID-19. Do not read this post as a medical advice. It is solely intended for entertainment purpose.

Consider all the following to be the same;

  • Coronavirus (popular name of the virus)
  • SARS-CoV-2 (official name of the virus)
  • COVID-19 (official name of the disease caused by the virus)

How COVID-19 Attacks us With Fear Porn

Surely many of the readers are not afraid, but I know that some are fretting in anxiety and sweat bullets. Let me ease your mind.

I will not dismiss the seriousness of this virus. We see Italy and Spain now, and how the health care system is struggling. But we can all see how COVID-19 attacks us not only in the lungs, but also by fear.

The so called mainstream media that we’ve trusted lifelong, is now filling the internet with exaggerated, rigged, censored and even duplicate news.

We do know that the vast majority will survive. But maybe you’re like me and got thinking “what if I’m genetically susceptible to having severe symptoms?..” That is why I’ve compiled a list of how COVID-19 attacks the host, so you can understand the mechanisms, and learn what foods and lifestyles to avoid during the pandemic.

In the previous post we discussed some potential compounds to inhibit SARS-CoV-2.

How COVID-19 Attacks

 

1. ACE2COVID-19 attacks the host through ACE2

ACE2 is short for angiotensin converting enzyme 2. This sparks special interest for many as SARS-CoV and SARS-CoV-2 enters the host’s lungs through ACE2 [1][2][3]. ACE2 is closely tied to cardiac function, blood pressure, and kidney function.

ACE, AGRT1, and REN are closely tied expressions to ACE2. We don’t know if lowering these expressions will ameliorate the symptoms of COVID-19, or if it’s even safe. This is only theoretical, and it should be done under the supervision of a physician, unless if you’re just avoiding the unhealthy stuff.

What Increases ACE, AGRT1, and REN (rather avoid):

  • Excessive salt intake
  • Excessive glucose
  • Alcohol
  • Nicotine
  • Crack Cocaine
  • Arsenic
  • Yohimbine
  • Methylfolate

Neutral

  • Silver (increases ACE but decreases REN)                     (iHerb)
  • Zinc (lowers ACE but increases REN)                              (iHerbAmazon)
  • Forskolin (helps lung function but increases REN)          (iHerb)
  • Lipoic Acid (modulating effect)                                         (IHerbAmazon)
  • NAC (modulating effect. Helps with lung function)            (iHerbAmazon)

What lowers ACE, AGRT1, or REN (Favourable, but take at your own  risk)

2. Hypertension

There was many discussion on high blood pressure increasing the risk of severe cases and death in COVID-19. This is likely due to increase in ACE2 expression [4][1].

Excess weight often contributes to increased blood pressure. Avoid excessive salt and added sugar as they will lead to increased blood pressure. The industrial vegetable oils high in polyunsaturated fats should be shunned for now; canola oil, nut oils, soybean oil, sesame seed oil, etc.

3. IL-6 & TNF

I’ll start off by saying that some immune enhancers may do more harm than good. This is due to what is called cytokine storms. We will discuss the effects interleukin-6 (IL-6) and tumor necrosis factor (TNF) on pneumonia.

The number one cause of suffering and death due to COVID-19 is pneumonia. Inflammatory cytokine responses, IL-6 and TNF are implicated in pneumonia [5]. IL-6 and TNF are activated to fight off infections, which would be good in most cases, but not when there’s pneumonia risk present.

IL-6 and TNF are elevated initially during pneumonia, and then IL-10 (anti-inflammatory response) spikes rapidly to compensate for that [6]. If IL-6 does not spike, then neither will IL-10 [5].

So we will want to minimize consumables that will spike IL-6 and TNF. What elevates IL-6 and TNF are pretty much the same; unbalanced, unclean, and unconscious diet and lifestyle.

What elevates IL-6 and TNF (avoid)

  • Inflammation
  • EMF exposure [20]
  • Smoking tobacco
  • Excess alcohol (5 or more drinks per session).
  • High blood sugar
  • Lack of sleep
  • Gluten and lectins
  • Too little or too much exercise
  • Viral infections
  • Bacterial infections
  • Lack of vitamin D, vitamin C, Magnesium, and zinc

Supplements & drugs that elevate IL-6 & TNF (avoid)

  • Goji berries
  • Royal Jelly
  • Reishi
  • Cat’s claw
  • Grapeseed extract
  • Astragalus
  • Imipramine
  • Venlafaxine

Supplements that decrease IL-6 & TNF (favourable)

During the evening, only take lithium, inositol, or curcumin, as to avoid insomnia. Otherwise, just focus on not increasing IL-6 and TNF in the first place.

4. Ibuprofen…Ibuprofen might increase the symptoms of COVID-19

We don’t exactly know if or how COVID-19 attacks harder when ibuprofen is taken by a patient. Fair number of those who are in serious condition with COVID-19 are reporting to have been taking ibuprofen. Few reports suggest that ibuprofen can cause an onset of severe symptoms. Rather avoid.

5. Pneumonia

The number one cause of suffering and death due to COVID-19 is pneumonia. So by all means avoid unhealthy lifestyle that spikes IL-6 and TNF.

Zinc deficiency may make you more susceptible to pneumonia [7]. Zinc supplementation may reduce the chance of death from pneumonia [8]. (iHerbAmazon)

Vitamin C will likely not pose any adverse effects to those suffering from pneumonia. Supplementing vitamin C with proper pneumonia treatments might be reasonable [9, 10]. Hospitals in New York and China are using vitamin C in some COVID-19 patients. (IHerb, Amazon)

NAC may improve influenza induced pneumonia and community acquired pneumonia [11, 12]. NAC is also known elevate glutathione and aids in lung function.  (IHerb, Amazon)

Vitamin D may reduce the risk of respiratory infection. A research from Dublin has found that Vitamin D can help fight off an infection [13]. During the Spanish flu, the patients that were treated outdoor, exposed to the sun, had less severe symptoms and recovered faster. (iHerb)

Forskolin is known to support lung function, mainly aiding asthma. (iHerb)

Quercetin is a bronchial dilator and has antiviral activity. (iHerb, Amazon)

Ephedrine is a bronchial dilator and can blunt some energy sapping aspect of viral illnesses. It does raise blood pressure, however.

6. Lack of Melatonin?Why kids are more resistant to COVID-19

How COVID-19 attacks older people harshly, while kids withstand like tanks, is a mystery. We could say that it’s because older people have less antioxidant capacities and more inflammation. But that is why the melatonin topic should be brought up. The younger you are, the more of this hormone you will produce.

Melatonin is released during the night as a sleep signal. The modern lifestyle of constant exposure to artificial lights from screens and streets disrupts it’s production. It’s a common phenomenon for older people to develop insomnia because they produce less melatonin as they age. Think of grandparents that always wake up early.

Melatonin significantly decreases IL-6 and TNF expression, while increasing IL-10. We have learned that managing IL-6 and TNF might reduce pneumonia risk. Melatonin also acts as an immune modulator, thus having anti-influenza effects. It is well known to reduce acute lung injury and acute respiratory distress syndrome in other viral illnesses [14].

Melatonin is able to reduce the fatality rate, postpone the symptom onset, and increase host’s resilience to several different viral illnesses [15].

Melatonin lacks known toxicity and has a very high safety profile.

(iHerbAmazon)

7. Seizures?

The most spine chilling effect of COVID-19 might just be the sudden convulsion that leads to death. We don’t know exactly why this happens yet, but we can at least take measures to reduce seizure risks.

For this purpose, we want to be looking at glutamate. Glutamate is a neuron in the central nervous system that opposes GABA. Think of GABA as being drunk, sedated, and numb. Think of glutamate as convulsion, anxiety, and overexcitation.

Image result for gaba vs glutamate

Excessive glutamate is implicated in seizures and mania. People may have excessive glutamate due to unhealthy lifestyles.

Consumables and Lifestyles that Raises Glutamate (Avoid)

  • Gluten
  • Dairy
  • Alcohol
  • Caffeine
  • Aspartame
  • MSG
  • Glutamine
  • Stress
  • Sleep deprivation

8. Low Nitric Oxide?

Nitric oxide (NO) is a molecule most notable for promoting cardiovascular and circulatory health. It is also known to have an antimicrobial effect and can inhibit some virus types.

NO inhibited the replication cycle of the past coronavirus, SARS. Treatment with inhaled NO was able to reduce time on ventilation support, reverse severe pulmonary hypertention, and improved hypoxia in SARS [16][17].

Whether if NO can inhibit coronavirus that causes COVID-19 is unknown, though the idea has already been proposed [18][19].

COVID-19 is known to be a blood blocking disease. NO can dilate (widen) blood vessels. Something to think about.

Raising NO is generally considered to be safe for healthy individuals. You should consult your doctor if you have any heart or circulatory conditions.

Nutrients that may raise nitric oxide:

Final Mention on How COVID-19 Attacks

Thank you to all those that commented on the previous post. Because of you I was able to find out about melatonin connection and nitric oxide connection. This post will be updated more as we go.

Questions or suggestions? Type in the comment section below.

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Read Part I: How to Inhibit coronavirus