The original post became too long so they’re split into two. This is a part 1 discussing how to inhibit SARS-CoV-2. Part 2 will discuss the ways this virus attacks the host and ways to mitigate it.

Disclaimer

We will discuss the potential ways to inhibit SARS-CoV-2, the new coronavirus. The author does not intend to diagnose, treat, or cure COVID-19. Do not read this post as a medical advice. It is solely intended for entertainment purpose.

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Consider all the following to be the same;

  • Coronavirus (popular name of the virus)
  • SARS-CoV-2 (official name of the virus)
  • COVID-19 (official name of the disease caused by the virus)

The Properties of SARS-CoV-2

Infection and Death Rate

The infection rate is 83% upon exposure to the virus, and the death rate is 15%; according to The Lancet [4]. That would explain why a country like China would shut down the whole system in lock down. Still, the death rate isn’t high enough to worry the individuals who are willing to make healthier lifestyle choices during the pandemic.

Another research estimates the fatality rate of the COVID-19 to be 6.5%, and the R0 (R-naught) of the virus to be 4.08 [27].

To keep it simple, R0 shows how many people one infected person will transmit the disease to. So if Ro=4, then the number of total infected people will quadruple. 1 – 4 – 16 – 64 – 256 – 1024 – 4096…

Ro does not specify the time frame which the numbers multiply. However, we are seeing a doubling rate of 3.5 days when there is no measurements being taken to contain the virus. If everyone wore a mask, practiced social distancing, and adhered to quarantine, then the Ro can be brought down.

Los Alamos estimates the Ro of the SARS-CoV-2 to be between 4.7 – 6.6 [1]. Ro=4 or higher is considered to be not containable unless if draconian measures are taken. The common flu has Ro of less than 2.

Incubation Period

The incubation period of the COVID-19 is anywhere between 1-27 days after exposure to the virus. Chinese officials confirmed that the virus can be transmitted during the incubation period [8].

One may test negative, yet be able to spread the virus, and then test positive later. It can take up to 5 testings to find out if you’re COVID-19 positive.

Transmissibility

Contrary to the claims of health officials like WHO, several other sources suggest that SARS-CoV-2 is airborne and it spreads through the aerosol. Airplanes with recycled air is the perfect breeding ground for the virus. Feces can aerosolize SARS-CoV-2, thus using public toilets will also pose risk.

Reinfection

Reinfection has been documented with COVID-19. If a pharmaceutical antiviral has been used in the first round of infection, it may cause heart tissue damage, which then the patient becomes less resilient during the second infection. There are not enough cases to solidify this.

HIV Protein Sequencing

Indian researchers found 4 protein gene coding of HIV in the SARS-CoV-2. They called this phenomenon “uncanny” [R]. They don’t know how it ended up in there, or how it influence it’s virulence.

No, you will not get HIV AIDS by catching SARS-CoV-2. Most people that recover from COVID-19 seems to test negative of SARS-CoV-2. But some still test positive for sometime.

SARS-CoV-2 is an Enveloped Virus

Image result for enveloped virus vs non enveloped virus

SARS-CoV-2 and other coronaviruses are enveloped virus. So they have lipid bilayer to protect the capsid of the virus.

Enveloped viruses are efficient at sticking onto their target cells. This is due to their lipid coating. They are overall more stable and tend to survive longer, thus causing recurrent infections. Some examples are herpes and HIV.

Another thing that lipid enveloped viruses are capable of is; quickly changing their surface appearance. This way, they can disguise themselves to bypass the host’s immune system without being detected.

Examples of lipid coated viruses

  • Ebola
  • Coronavirus (SARS-CoV, SARS-CoV-2 & MERS)
  • HIV
  • Rhabdovirus (rabies)
  • Herpes
  • EBV
  • Cytomegalovirus
  • Hepatitis C
  • H1N1 (Spanish flu)

The Good News

Lipid coated viruses have similar vulnerabilities. For one, they can’t stand desiccation (loss of moisture)  and heat. They also cannot tolerate acidic environment at all. Alcohol or heat will sterilize the enveloped viruses almost instantly.

So do we start chugging hard liquor, eat tons of acidic foods, and take hot baths 24/7? Is that how we’re going to inhibit SARS-CoV-2?

No, because that won’t be good for the immune system. The good news is that lipid coated viruses have similar vulnerabilities. So the way to inhibit SARS-CoV-2 might just be similar or identical to fighting other enveloped virusesl.

Can We Inhibit SARS-CoV-2?

At this point we don’t really know that much because of how fast this virus is spreading.

We do know that the SARS-CoV-2 is a lipid enveloped virus, and it is related to SARS, MERS, and rest of the coronaviruses. We also know that lipid enveloped viruses share similar vulnerabilities.

So we can look into compounds that may inhibit SARS-CoV-2 by looking at what lipid enveloped viruses are generally vulnerable to.

The SARS-CoV-2 contains four HIV-1 protein inserts [9]. This has raised questions on whether it was bio-engineered. Either way, HIV protease inhibitor was able to powerfully inhibit SARS-CoV-2, the past version, SARS [10].

China is now looking to use protease inhibitors (HIV meds) to combat COVID-19 [11]. Flu and HIV meds may help as Thailand just successfully treated a patient. Anti-malaria compounds are also potential candidates.

Protease inhibitors are a class of antivirals that are used to treat HIV and Hepatitis C. Protease inhibitors can bind to the viral protease of HIV and block their replication by cutting off their food supply.

Whether if we should use HIV treatment to inhibit SARS-CoV-2 is a good question. It might be the best option we have for now because most countries have only caught onto treating the symptoms of COVID-19. But the hospitals will be easily overrun during full blown epidemic.

We will also look into potential deficiencies that may be implicated in viral mutations and infections.

Medical VS Holistic Intervention to Inhibit SARS-CoV-2

The hospitals in US and Canada already has very low capacities. The emergency room wait times are usually over an hour. Sometimes people wait for 8 hours or more.

The question we want to ask ourselves is, would hospitals of any country have the capacity to handle a full blown epidemic?

As far as antivirals go, you could try to convince a doctor to prescribe some expensive protease inhibitors with side effects. But then there are antivirals that are produced by nature.

When it comes to antipsychotics and antianxiety, the pharmaceutics will prove to be more effective. When it comes to antibacterials and antivirals, nature offers superior candidates.

With pharmaceutical antibiotics, we often hear of the birth of dangerous superbugs and major harm done to the good bacteria in the gut. Natural antibacterials are capable of inhibiting antibiotic resistant strains of bad bacteria, while mostly leaving the good bacteria unharmed.

Similarly with natural antivirals, they are capable of killing strains that pharmaceutical antivirals cannot. Many use natural antivirals after continuous failures with pharmaceuticals, and then achieving desired results.

Compounds That May Inhibit SARS-CoV-2

EGCg

EGCg (epigallocatechin gallate) has been shown to inhibit proteases involved in cancer metastasis and infection by influenza virus and HIV [12]

EGCg has been shown to damage or alter most lipid enveloped virus particles. This includes HIV, HCV, influenza, and HSV [13].

EGCg is able to bind to HIV-1 and prevent it from infecting the targeted cell [14][15].

From the researches gathered, EGCg might be a reliable tool to inhibit SARS-CoV-2. It can dampen inflammatory response by TNF [31].

Taking it with food will reduce oral bio-availability [32] So take on empty stomach, once a day.

iHerb   Amazon

BHT

Stands for Butylated Hydroxytoluene. This compound is most often used in foods and beauty products as a preservative and an antioxidant.

Basically, any lipid enveloped virus that stood a trial against this compound were deactivated. It deactivates the enveloped viruses by stripping off their lipid coating.

The unfortunate thing is that BHT cannot have a human clinical trial because FDA has approved BHT use only as a food preservative, and not as a medicine.

In the last two decades, herpes carriers who were desperate used it as a prophylactic for breakouts. There have been cases of patients that used over a gram BHT a day for over a year, coming back herpes negative.

Steven Fowkes Book on Curing Herpes with BHT

BHT is less likely to have immune stimulating properties, and it is very inexpensive. I would personally use this as the main arsenal to inhibit SARS-CoV-2.

Take with a fatty meal. Start at 100-200 mg a day, and build up the dose slowly to 500 mg over the course of 2 weeks.

Purchase BHT at iHerb

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Monolaurin

Coconut oil contains 50% lauric acid, which is a precursor to monolaurin. Taking monolaurin directly is much more potent than eating coconut oil, however. Breast milk contains lauric acid and it is known to be antiviral.

Monolaurin shows powerful activity against lipid enveloped viruses. Even in low temperature environment, enveloped viruses showed extreme sensitivity to Monolaurin [16][17].

Same as BHT, it inhibited every lipid enveloped virus it’s been tested against [18].

Monolaurin may treat Alzheimer’s by inhibiting herpes (enveloped virus) [19]. Although the evidence is lacking, it may be effective in treating in memory impairment [20]. I mention this because it poses the potential of monolaurin being able affect the viruses in the nervous system, which is hard to do.

Monolaurin is likely to inhibit viruses by disintegrating their outer membranes (lipid envelope) [21].

So will monolaurin be useful to inhibit SARS-CoV-2? It has deactivated every lipid enveloped viruses it’s been tested against. My guess would be; highly likely.

Take with food. If you’re using the brand from the link below, take 2 caps a day. If you start to feel sick then bump up the dose to 6 – 10 caps a day.

iHerb  Amazon

Selenium

Selenium deficiency may have extremely high implication in viral infections and mutations [5][6][7].

Selenium deficiency leads to low glutathione levels. The selenium deficient regions are more susceptible to HIV infections in the population [22].

HIV infection rates are the highest where selenium intake is the lowest. African countries with AIDS rates, Zimbabwe 26%, Botswana 25%, Zambia 19%, South Africa 13%.

If we take a look at Senegal, where they have the highest level of selenium rich soil in Africa, they have AIDS rate of 1.77%.

China has a very widespread selenium deficiency. It’s also where many viruses mutate into much more powerful strains.

If you plan on taking selenium, you might as well take the selenomethionine, the yeast free form. Take with food once a day. If you’re seriously deficient then take it with Vitamin E to increase absorption.

Purchase Selenomethionine at iHerb

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Spirulina to inhibit coronavirus?

Spirulina (Green Blue Algae)

Spirulina (green blue algae) has recently came on the market as a super food and nutrient dense supplement.

Spirulina have antioxidant, anti-cancer, immunomodulating, and antiviral properties [23][24]

According to Journal of Microbiology and Biotechnology, green blue algae contains a very powerful protease inhibitors [25].

Spirulina is capable of inhibiting several lipid enveloped viruses such as herpes, HIV, and cytomegalovirus [26].

It inhibits IL-6 [30] so it may also be helpful in reducing the autoimmunity caused by the SARS-CoV-2. It does raise other immune departments, but not IL-6.

Don’t take it too late in the day as it can be stimulating. Take it with or without food. 3000 – 4000 mg will suffice.

Purchase Spirulina at iHerb

Fullerene C60

This is a relatively unknown supplement that has recently started being widely available.

C60 is used as an antioxidant, immune enhancer, and anti-aging. The antioxidant effect of C60 is said to be so strong, that it exceeds the capacity of glutathione, the mother of all antioxidants. C60 were able to consistently double the lifespan of rats.

C60 has HIV protease inhibiting and binding capability [49]. In studies, C60 displays antiviral activity against herpes, cytomegalovirus, and HIV, which are all lipid enveloped viruses [47][48].

Could the ability of C60 to be stored in the body offer superior antiviral activity compared to others?

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Final Mention

That is all for the potential ways to inhibit SARS-CoV-2. This post will be updated as time goes on to add more scientific researches on this matter.

Questions or suggestions? Type in the comment section below. If you find any conflicting information to this post on how to inhibit SARS-CoV-2, please inform.

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