This is a quick and easy to read, evidence based, and extremely effective guideline on how to minimize aging and inflammation and hangover. Yes you can still get drunk and have fun!
The Damages of Alcohol
Alcohol causes a heavy duty, dose dependent, and crippling hangover. It does so by converting into acetaldehyde, a toxic metabolite that is 30 times more toxic than alcohol.
Acetaldehyde encourages dehydration, inflammatory response, and glutamine rebound. This process harshly accelerates aging, and damages the brain. Puffiness, red cheeks, wrinkles, and a lack of glow can occur even from moderate drinking.
Ways to Prevent Hangover and Inflammation
1. Types of Drinks
This is a crucial step in preventing hangovers and minimizing damage. Sweet booze are notorious for causing hangovers. If you absolutely love sweet alcoholic drinks then we recommend keeping it to no more than one drink per night.
Black List (Avoid)
- Sweet alcoholic drinks
- Chasing hard liquor with sodas and pops (diet sodas are okay)
- Mixing booze with energy drinks that are sweetened with sugar
- Sourpuss, Palm Bay
- Any form of sugar throughout the night including fruits and honey
Keep it to one drink… two if you must
- Fire Ball
- Southern Comfort
- Red wine
- Dry white wine
Go hard if you must (make sure they’re not sweet)
Additionally, make sure you’re not taking any GABA agonists when you’re drinking. Not only can it greatly increase the risk of landing into a coma, it can speed up intoxication and drastically exasperate hangover symptoms.
List of common GABA agonists
- Benzodiazepines (xanax, lorazepam)
- Barbituates (phenobarbital)
- Z drugs (ambien, zopiclone)
- Ketamine (indirect GABA enhancer)
- Memantine (indirect GABA enhancer)
- Roofies (GHB, GLB)
2. Staying Hydrated
For every alcoholic drink you have, drink a glass of water. Add some salt or squeeze some lemon into your water if they’re available.
Don’t wait until the end of the night to pay off all of your dehydration debt because the body can only absorb so much water at a time.
This is the most important step. Do everything else right, but if you skip this step, then the purpose is not served.
Generally, the more drinks we have, the less mindful we become of the well-being of our future selves. Let’s be loving and kind to our future selves. Drink some water.
3. Take Some Supplements
What follows is a list of supplements you can take to prevent the hangovers and to reduce the acetaldehyde build up. The general rule you can follow is to pick 3 supplements from the list. Make sure to include Vitamin C in your stack. Take more if you’re unfollowing other steps, or if you plan on getting hammered.
Most important one. Cheap and easy to find.
Vitamin C blocks the conversion of alcohol to acetaldehyde. As we discussed earlier on in this post, acetaldehyde is 30 times more toxic than alcohol.
Vitamin C is an antioxidant and it promotes the synthesis of glutathione.
Definitely take one with your first drink and one at the end of your session. Taking some in between doses isn’t a bad idea.
There is an article about one guy that spent 10 years drinking to find the best hangover cure. The list were: activated charcoal, Gatorade, and some sort of liquid drop. It is sad that he had spent 10 years only to come up with those three. At least it shows us how effective the charcoal is though.
Take a few caps with your first drink, and then take a few at the end of the session. Taking some in between isn’t a bad idea.
Solid research is lacking for this one, but people swear by it. It’s super cheap too.
Thiamine decreases mortality rate by acetaldehyde administration in mice, more effectively than vitamin C.
Alcohol depletes this vitamin out of your body so replenishing it is helpful. And for that, it’s not surprising that it’s a great hangover prophylactic. Another cheap supplement that you can take.
Take one with your first drink. Vitamin B1 can be stimulating so if you want to go to sleep then don’t take another dose. If you want to you can take a B complex instead.
In the Japanese convenience stores, they sell this drink that is loaded with curcumin. People drink it with their first drink to prevent the hangovers.
Curcumin is an antioxidant that is extracted out of a common spice, turmeric. It can be pricey, but it has many other benefits so it’s worth having around.
Curcumin reduces acetaldehyde (toxic metabolite of alcohol) accumulation and it protects the liver. Take one with your first drink, or little bit before that.
NAC (N-Acetyl Cysteine)
Precursor to glutathione, the most powerful antioxidant known to man.
NAC can protect the liver from damages inflicted from alcohol and also aids in the overall detoxification process. It can also reduce the acetaldehyde concentration during alcohol exposure.
NAC modulates glutamate, the GABA opposing neuron, so it could be a good thing to take in the morning after as well.
Combining it with Vitamin C and ALA will result in greater glutathione production.
Take one with your first drink, and one with your last. Take one in the next morning if you remember to.
A very potent antioxidant that raises glutathione.
It promotes mitochondrial function and that’s important in the body’s detox mechanism. It may prevent alcohol induced hippocammpus damage. ALA can help recycle vitamin C and E in the body.
You want the sodium stabilized R – Lipoic Acid. It is more capable at raising peak blood concentrations of lipoic acid, and with longer half life.
This nutrient comes from broccoli and broccoli sprouts. It upregulates acetaldehyde dehydrogenase, which allows for a faster excretion of acetaldehyde from the body.
If you have an alcohol intolerance, then sulforaphane may help.
This one is little expensive but it has many other health benefits that are worth looking into. Take it with your first drink.
For Regular Drinkers
If you have more than 5 drinks per week on average then you’d benefit from additional measurements.
Reducing Inflammation calls for more favorable outcome.
Resveratrol is a powerful anti-aging support.
Coenzyme Q10 supports the mitochondria.
Magnesium depletion is hastened in the presence of alcohol.
Omega 3 may minimize hangover symptoms.
Milk Thistle is a very helpful liver support.